[Tyra Talk] 2025-04-19 嗜中性白血球的遺產-LANDV 止戈為武，澤被後世
免疫系統是我們身體的守護者，而白血球在其中扮演極重要的角色。它們就像是警衛一樣，隨時巡邏身體，一旦發現外來入侵者，就會立刻發出警報，召集其他白血球一起消滅敵人。然而，許博士的研究卻發現，有一類嗜中性白血球（neutrophils）竟然具有雙重身份！它們不僅是消滅敵人的戰士，還能產生抗發炎的細胞外囊泡，幫助身體解除發炎反應。這項突破性的發現，為治療發炎和傳染性疾病帶來了新的希望。
|| 講者（Speaker）:
I was born in Providence, Rhode Island, and finished elementary school before moving back to Taiwan with my parents, where I subsequently attended middle and high school. When I just moved to Taiwan, I was strongly allergic to mosquito bites and would develop areas of rashes and blisters (still do). Coincidently, Dengue fever was an epidemic at the time, combined with my severe mosquito bite reactions I was constantly fearful of contracting Dengue. Thus when it came time to decide my college major I choose Medicine with sub-specialty in infectious diseases in hope to understand what I feared most as a child-Dengue virus at National Cheng Kung University (NCKU) in Taiwan. During my internship, I met Dr. Guey-Chuen Perng who had just been recruited to NCKU from Emory. His research interests inspired me greatly to think about fundamental issues which were not yet known in the field of Dengue, such as the permissive cells to Dengue virus in the bone marrow leading to bone marrow hypocellularity and visualizing the viral morphology which circulates in dengue patients. Through this work, I gradually gained interest in medical research, but felt that I needed more training on the fundamental biology background and critical thinking as wells exposing myself to more technical aspects of how science/research is done. Thus I opted to pursue a Ph.D in biological sciences at Purdue University, where I originally wished to study structural biology in the context of illustrating viral structures in vivo. However, through my rotation, I gradually found that I liked cell biology and immunology where I could see the magic happen more interesting and joined the lab of Dr. Qing Deng to study neutrophil biology and microRNAs. It was during my Ph.D. where I learned the complexity of neutrophils and the important and indispensable role they play in our immune system. It was a tough decision to make when pursuing postdoctoral training, as part of me wanted to return to virology research and the other part to continue neutrophil research. In the end I decided to Join Dr. Hongbo Luo’s lab to continue learning and studying neutrophil biology as during my Ph.D. my focus was neutrophil migration and recruitment, whereas now I have expanded my horizons to study neutrophil death and basic biology of these volatile cells. My current research revolves around understanding why and how neutrophils being the most abundant WBC had such an evolutionarily conserved short life span. Where now my journey has uncovered another function of neutrophils during their aging, where neutrophils form large vesicles to module neutrophilic inflammation and aid in resolution. This opens up a avenue of a field to study these vesicles and “life beyond death” for these short lived cells, and their importance as extends beyond inflammation but also host homeostasis.
|| 摘要（Abstract）:
Although subsets with immunosuppressive properties exist, neutrophils are typically known for their pro-inflammatory role and pathogen clearance capabilities. Here, we reveal that neutrophils can paradoxically aid in resolving inflammation by actively producing anti-inflammatory extracellular vesicles. These large aging neutrophil-derived vesicles (LAND-Vs) did not fit into classical vesicle categorizations due to their specific size, structure, or biogenesis pathway. They were protected from efferocytotic clearance by phagocytes due to surface “don’t eat-me” signals and accumulated in the resolution phase of inflammation. CD55 on LAND-Vs exerted a robust, sustained anti-inflammatory effect by inhibiting complement 3 convertase, thereby reducing neutrophil recruitment and tissue damage. CD55+ LAND-Vs originated in ordered lipid raft domains, where CD55 accumulated asymmetrically during neutrophil aging, and were subsequently formed through RhoA-dependent budding. Collectively, LAND-V emerges as a pivotal physiological immunomodulator and showcases functions that transcend the limited lifespan of neutrophils, offering a therapeutic target for inflammatory and infectious diseases.
|| 研究領域（Field）:
自然科學、數學及統計領域
|| 研究子領域（Sub-field）:
免疫學、細胞生物學
|| 主持人（Chair）:
|| 活動時間（Event Time）:
04/19/2025 06:00 PM PDT Pacific Time
04/19/2025 07:00 PM MDT Mountain Time
04/19/2025 08:00 PM CDT Central Time
04/19/2025 09:00 PM EDT Eastern Time
04/20/2025 02:00 AM BST England
04/20/2025 03:00 AM CEST Berlin
04/20/2025 09:00 AM Taiwan
|| 圖像設計（Design）:
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